Endocrine Abstracts

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RCTs and real-life studies have shown the efficacy of GLP-1 RAs on weight loss, glycemic outcomes, and prevention of cardiovascular (CV) events, but long-term data are lacking. This was a retrospective cohort study of 253 patients with a first prescription of a GLP-1 RA between 2009 and 2016 and a minimum follow-up of 5 years. The endpoints of the study were weight and glycemic outcomes. Secondary endpoints were the occurrence of renal and CV events, comparing patients with GL...

Radium-223 was associated with high incidence of non-vertebral fractures in patients with castration-resistant prostate cancer (CRPC). The determinants of this effect are unknown and it is still unclear whether Radium-223 may induce skeletal fragility regardless of other therapies of CRPC. We aimed at evaluating the incidence and determinants of vertebral fractures (VFs), i.e. the hallmark of skeletal fragility, in CRCP patients undergoing Radium-223 therapy in the real-life c...

Objective: Somatostatin analogues (SSA) are widely used for the treatment of patients with neuroendocrine tumors. These drugs are able to influence glucose metabolism by an inhibitory effect of insulin secretion, but the clinical impact of this effect is uncertain. Most of the data on this topic have been obtained from studies including patients in acromegaly, one the major indication for SSA, which are limited in terms of numerosity and study duration. Therefore, we have carr...

Introduction: Osteoporosis and vertebral fractures (VFs) commonly occur in overt and subclinical primary hyperthyroidism. In this clinical setting, bone damage is caused by the direct effects of thyroid hormone in excess on bone remodeling, although there is also evidence that low thyrotropin (TSH) values may play a role in driving fracture risk. In fact, TSH was shown to have direct inhibitory effects on osteoclastogenesis and bone resorption. Based on these data, one could a...

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is showing a rapid and continuous evolution in terms of new waves, the spread of variants and the evidence of reinfections. The growing heterogeneity of clinical presentation requires the identification of underlying pathogenic mechanisms to allow a better risk stratification. Previous studies analysed the role of sex hormones in disease severity demonstrating in male patients the association of...

Background: In the last decades mini-invasive techniques have been proposed to reduce costs and complications of emithyroidectomy and thyroidectomy, both for benign nodular goiter and thyroid microcarcinoma, and image-guided laser and radiofrequency ablation are the most used.Purpose: To investigate short and long-term efficacy of image-guided laser and radiofrequency ablation as therapy options for benign nodular goiter.Methods: F...

Background: The fourth type of Multiple Endocrine Neoplasia (MEN) is a rare variant of MEN presenting a MEN1-like phenotype and originating from a germline mutation in CDKN1B. However, due to the small number of cases documented in literature, the peculiar clinical features of MEN4 are still largely unknown, and clear indications about the clinical management of these patients are currently lacking. In order to enlarge our knowledge on MEN4 and to better typify the clinical fe...

Chronic hypercortisolism is associated with dramatic increase in fragility fractures. The evaluation of skeletal fragility in Cushing’s syndrome (CS) is a clinical challenge, since fractures may occur even in presence of normal bone mineral density (BMD). Recently, measurement of bone marrow fat (BMF) by vertebral magnetic resonance spectroscopy (MRS) was proposed as alternative tool for evaluating skeletal fragility in primary and secondary osteoporosis. Noteworthy, rece...

Acromegalic osteopathy is an emerging complication of chronic GH excess characterized by increase in bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures (VFs). Medical therapies may exert direct effects on peripheral targets leading to improvement of clinical outcomes regardless of biochemical control of acromegaly. In this longitudinal study, we compared the effects pegvisomant (PegV) and somatostatin receptor ligands (SRLs) on VF risk ...